Tofranil is used for:
Treating depression. It is also used in some children to help reduce bedwetting. It may also be used for other conditions as determined by your doctor.
Tofranil is a tricyclic antidepressant. It works by increasing the activity of certain chemicals in the brain that help elevate mood.
Do NOT use Tofranil if:
you are allergic to any ingredient in Tofranil
you have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
you are recovering from a recent heart attack
Contact your doctor or health care provider right away if any of these apply to you.
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Before using Tofranil:
Some medical conditions may interact with Tofranil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you drink alcohol or have a history of alcohol abuse
if you take thyroid medicine or you have a history of an overactive thyroid, glaucoma or increased pressure in the eye, heart problems, kidney or liver problems, diabetes, seizures, the blood disease porphyria, or difficulty urinating
if you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders; you are undergoing electroshock therapy; or you are scheduled to have any surgery
if you are taking a medicine that contains methylene blue
Some MEDICINES MAY INTERACT with Tofranil. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Buspirone, cimetidine, fentanyl, flecainide, lithium, methylphenidate, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), St. John's wort, tramadol, or tryptophan because they may increase the risk of Tofranil's side effects
- Linezolid or MAOIs (eg, phenelzine) because the risk of high blood pressure or serious heart problems (eg, irregular heartbeat) may be increased
- Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Tofranil's effectiveness
- Anticholinergics (eg, benztropine) or sympathomimetics (eg, phenylephrine) because the risk of their side effects may be increased by Tofranil
- Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by Tofranil
This may not be a complete list of all interactions that may occur. Ask your health care provider if Tofranil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.