Primaquine - Primaquine is an antimalarial drug. The exact way that Primaquine works is unknown.
Primaquine is used to treat and prevent malaria.
Primaquine may also be used for purposes other than those listed in this medication guide.
Used for: Preventing a relapse of malaria caused by the vivax malaria organism. It may also be used for other conditions as determined by your doctor.
Primaquine is an aminoquinoline. It works by preventing the development of the blood forms of the organism, which cause relapses of vivax malaria.
Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria. In the blood, malaria parasites break down a part of the red blood cells known as haemoglobin. When this happens haemoglobin is divided into two parts; haem and globin. Haem is toxic to the malaria parasite. To prevent it from being damaged, the malaria parasite produces an chemical which converts the toxic haem into a non-toxic product. Primaquine acts by interfering with a part of the parasite (mitochondria) that is responsible for supplying it with energy. Without energy the parasite dies. This stops the infection from continuing and allows the person to recover. Primaquine kills the intrahepatic form of Plasmodium vivax and Plasmodium ovale, and thereby prevents the development of the erythrocytic forms that are responsible for relapses (it also kills gametocytes). Primaquine is not used in the prevention of malaria, only in the treatment. It has insignificant activity against the asexual blood forms of the parasite and therefore it is always used in conjunction with a blood schizonticide and never as a single agent. Primaquine has gametocytocidal activity against all plasmodia, including P. falciparum.
Primaquine is used for the treatment and prevention of malaria. It is also used in the treatment of certain bacterial infections.
Oral Radical treatment of vivax or ovale malaria
Adult: A course of treatment with a blood schizontocide should be given first to kill any erythrocytic parasites. 15 mg daily for 14 days, increased to higher doses or longer course if resistance in P.vivax occurs.
Child: 250 mcg/kg daily for 14 days.
Oral Prophylaxis of chloroquine-resistant malaria
Adult: 30 mg once daily; to be started 1-2 days before travel and continue for 7 days after departure from the malaria-endemic area.
Child: 0.5 mg/kg once daily for 14 days. Max: 30 mg/day. Alternatively, for patients with mild G6PD deficiency: 45 mg once wkly for 8 wk. Special Populations: For patients with G6PD deficiency:
Adult: 30-45 mg/dose and children: 500-750 mcg/kg/dose. Dose to be taken once every 7 days for 8 wk.
Adult: PO Radical treatment of vivax or ovale malaria 15 mg/day for 14 days. Higher doses or longer courses may be required if resistance in P.vivax occurs. Prevention of chloroquine-resistant malaria 30 mg once daily; to be started 1-2 days before travel and continue for 7 days after departure from the malaria-endemic area.
Primaquine belongs to the group of medicines called antiprotozoals. It is used in the treatment of malaria, a red blood cell infection transmitted by the bite of a mosquito.