Treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). It may also be used for other conditions as determined by your doctor.
Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.
Do NOT use prednisolone if:
- you are allergic to any ingredient in prednisolone
- you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye
- you are scheduled to have a live or attenuated live vaccination (eg, smallpox)
- you are taking mifepristone
Contact your doctor or health care provider right away if any of these apply to you.
Before using prednisolone:
Some medical conditions may interact with prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems
- if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles
- if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test
- if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus
- if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)
- if you have had a recent vaccination (eg, smallpox)
Some MEDICINES MAY INTERACT with prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of prednisolone's side effects
- Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease prednisolone's effectiveness
- Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by prednisolone
- Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by prednisolone
This may not be a complete list of all interactions that may occur. Ask your health care provider if prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use prednisolone:
Use prednisolone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take prednisolone by mouth with food.
- Prednisolone comes as a dose pack with specific instructions as to when to take the medicine or how much to take each time. It is very important to follow these instructions as closely as possible. Do not miss any doses.
- If you miss a dose of prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use prednisolone.