Dostinex Product Description
Dostinex is a dopamine receptor agonist, which provides a direct inhibitory effect on lactotroph cells in the pituitary and reduces the secretion of prolactin. Antiprolactinaemic drug Dostinex is indicated to adult patients for:
- treatment of prolactinoma
- treatment of hyperprolactimaemic disorders
- suppression of lactation for medical reasons
Dostinex provides an antiprolactinaemic effect and acts selectively, without affecting basal secretion of other pituitary hormones. Besides, Dostinex can provide a hypotensive effect, which being dose-dependent, can last about 6 hours after oral administration.
The recommended dose of Dostinex is 0.25mg twice weekly (for example, Monday and Thursday). If required, the therapeutic dose of the antiprolactinaemic drug is gradually increased to 1mg twice a week. The maximum daily dose of Dostinex should not exceed 3 mg.
If you’ve forgotten to take a dose of Dostinex, do not worry and take a pill as soon as possible. If it is nearly the time for the next dose of Dostinex, do not take two doses at the same time, just skip the missed one and go back to taking your antiprolactinaemic drug on the recommended schedule.
Clinical investigations have demonstrated that absorption of dopamine receptor agonist Dostinex does not depend on meals. Yet, the patients are recommended to take the antiprolactinaemic drug during a meal, because the food improves drug tolerability.
Each increase of the therapeutic dose of Dostinex should be spaced by at least 4 week periods, it will help reduce risks of side effects during the treatment of hyperprolactinemia. In case of long-term application of Dostinex, it is recommended to undergo cardiological examinations regularly.
Dostinex should be stored at controlled room temperature up to 25°C in a tightly closed container to protect it from moisture.
Dostinex Safety Information
Postmarketing studies have revealed that some patients, taking high doses of Dostinex, may experience cardiac valvulopathy. If valvular heart disease is diagnosed, Dostinex application should be stopped and the physician to be seen. Since Dostinex is mainly metabolized in the liver, the patients with impaired liver function should take extra caution while on this drug. To reduce the risk of orthostatic hypotension, Dostinex is not recommended to be used in combination with antihypertensive drugs.
Information about prolactinoma contained in Dostinex review is for the informational purposes only and under no circumstances should be used to substitute for the endocrinologist’s consultation. The online pharmacy shall disclaim any liability for any consequences, which may occur due to improper use of the information, published in the review about Dostinex.
Dostinex Side Effects
Most Dostinex-associated adverse events depend on the dose of this drug. Lower doses of Dostinex can reduce the risk of adverse events. The most common adverse events of Dostinex include headache, dyspepsia, somnolence, dizziness, abdominal pain, gastritis, nausea, asthenia and fatigue. However, cessations of application of Dostinex are not reported often. About 3% of patients had to stop taking Dostinex tablets during clinical trials because of appeared adverse events.