Treating certain types of endometriosis or fibrocystic breast disease. It is also used to prevent attacks of hereditary angioedema (HAE). It may also be used for other conditions as determined by your doctor.
Danazol is a synthetic steroid. It works by decreasing the level of certain hormones, which reduces the symptoms and severity of the diseases treated by danazol.
Do NOT use danazol if:
- you are allergic to any ingredient in danazol
- you are pregnant or are breast-feeding
- you have undiagnosed abnormal vaginal bleeding
- you have the blood disease porphyria; an androgen-dependent tumor; or severe liver, kidney, or heart problems
- you have a blood clot, are at risk for blood clots, or have a history of blood clots or stroke
- you take simvastatin
Contact your doctor or health care provider right away if any of these apply to you.
Before using danazol:
Some medical conditions may interact with danazol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of the blood disease polycythemia, blood vessel problems, cancer (eg, breast cancer), diabetes, seizures, fluid retention (swelling), heart problems (eg, heart failure, heart disease), high blood pressure, high cholesterol levels, liver or kidney problems, or migraines
Some MEDICINES MAY INTERACT with danazol. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, sirolimus, certain statins (eg, atorvastatin, lovastatin, simvastatin), or tacrolimus because the risk of their side effects may be increased by danazol
- Insulin or other diabetes medicines (eg, glipizide) because their effectiveness may be decreased by danazol
This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use danazol:
Use danazol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take danazol by mouth with or without food.
- If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation.
- Endometriosis patients - You must take danazol consistently for 3 to 6 months. It may be necessary to take danazol for 9 months.
- If you miss a dose of danazol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use danazol.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking danazol:
For both females and malesLess common:
- dark-colored urine
- increased oiliness of the hair or skin
- muscle cramps or spasms
- rapid weight gain
- swelling of the feet or lower legs
- unusual tiredness or weakness
- Bleeding gums
- bloating, pain, or tenderness of the abdomen or stomach
- blood in the urine
- burning, numbness, pain, or tingling in all fingers except the smallest finger
- changes in vision
- chest pain
- complete or partial numbness or weakness on one side of body
- coughing up blood
- difficulty with speaking
- difficulty with swallowing
- discharge from the nipple
- eye pain
- fast heartbeat
- hives or other skin rash
- joint pain
- light-colored stools
- loss of appetite (continuing)
- loss of muscle coordination
- more frequent nosebleeds
- muscle aches
- purple- or red-colored, or other spots on the body or inside the mouth or nose
- shortness of breath
- sore throat
- tingling, numbness, or weakness in the legs, which may move upward to the arms, trunk, or face
- unusual bruising or bleeding
- unusual tiredness, weakness, or general feeling of illness
- yellow eyes or skin
For females onlyMore common:
- Decrease in the breast size
- irregular menstrual periods
- weight gain
- Enlarged clitoris
- hoarseness or deepening of voice
- unnatural hair growth
For males onlyRare
- Changes in semen
- decrease in the size of the testicles
Minor Side Effects
Some of the side effects that can occur with danazol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
For both females and malesLess common:
- Flushing or redness of the skin
- mood or mental changes
- Increased sensitivity of the skin to sunlight
For females onlyLess common:
- Burning, dryness, or itching of the vagina
- vaginal bleeding